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Journal of Biological Sciences
Year: 2004  |  Volume: 4  |  Issue: 4  |  Page No.: 470 - 473

Studies on the Chemical Composition and Presentation of Gallstones in Relation to Sex and Age among Human Population of Multan, Pakistan

Kamran Tassaduqe, Muhammad Ali, Abdus Salam, Muhammad Latif, Nazish Afroze, Samrah Masood and Soban Umar    

Abstract: The present study was carried out to investigate chemical composition of gallstones and their presentation in patients of different age groups of human population in Multan, Pakistan for a period of 18 months from August 2001 to January 2003. Gallstones were diagnosed by ultrasound and ultra sonography specifically in gallbladder and in bile duct. After cholecystectomy gallstones were washed, dried and analyzed by infrared spectroscopic and chemical method for various bio-chemical components. Of the 303 cases of gallstones, 274 (90.42%) were in gall bladder and 29 (9.57%) were in the bile duct. The predominant symptoms associated with gallstones were pain in hypochondrium, 164 (54.12%), vomiting 54 (17.82%), nausea 30 (9.90%), fever 38 (12.54%) and fatty food 17 (5.61%). According to the chemical composition of the gallstones, most of the stones examined in this study were of cholesterol 86 (28.30%), calcium oxalate 53 (17.40%), calcium phosphate 21 (6.90%), pure uric acid 31 (10.30%), pure bile 55 (18.40%) carbonate + magnesium 33 (10.80%) and others 24 (7.90%) were of mixed lithiasis. Of these cases the incidence of formation of cholesterol stone, was maximum in all age groups of both sexes.

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