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Journal of Biological Sciences

Year: 2004  |  Volume: 4  |  Issue: 2  |  Page No.: 212 - 215

Anti Yeast Activity of Some Plants Used in Traditional Herbal-medicine of Iran

G.H. Shahidi Bonjar


This is the first report showing the anti-yeast activities of different Iranian plants. Plants used in herbal-medicine were collected from South-East regions of Iran. Methanolic extracts were prepared and evaluated in Agar well-diffusion test against three yeast species of Saccharomyces cerevisiae, Candida albicans and C. utilis. From 48 plant species in 34 families, 26 species in 20 families showed inhibitory effect at least against one yeast species at 20 mg ml ha-1 . Plants with high anti-yeast activity included Alpinia officinarum, Chrozophora verbasafalia , Cinnamomum zeylanicum, Dianthus coryophyllus, Helleborus nigra, Heracleum persicum, Myrtus communis, Terminalia chebula and Trachysermum copticum which were effective mostly against C. albicans and C. utilis. No plant showed high level of activity against S. cerevisiae. The lowest MIC was observed in M. communis and T. chebula as 0.31 mg ml ha-1 . Active extracts retained their activity at room temperature in both DMSO: methanol (1:1, v/v) solvent and lyophilized state up to 18 months.

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