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Journal of Biological Sciences
Year: 2004  |  Volume: 4  |  Issue: 2  |  Page No.: 151 - 156

Preliminary Evaluation of Anethum graveolens Fruit in Indomethacin-ulcer Induced Rats

Rifat-uz-Zaman, Muhammad Shoaib Akhtar and Muhammad Shafiq Khan    

Abstract: Anethum graveolens, fruit has been used in the oriental medicine for the treatment of a variety of diseases including gastrointestinal disorders. The fruit powder of Anethum graveolens (AG) and its extracts were investigated for anti-secretary effects in rats with erosions on the glandular stomach induced by subcutaneous administration of 25 mg kg ha-1 indomethacin, to rationalize the folkloric uses. The pretreatment of AG protected the rats against gastric effects induced by indomethacin in a dose-dependent manner. The aqueous (AG-A) and ethanolic (AG-E) extracts (equivalent to 2.0 g kg ha-1 ) of the powder also attenuated the indomethacin-induced changes in gastric juice volume, pH, acid-output and ulcer index. AG and its extracts also showed significant acid buffering activities in vitro. The in vitro pepsin binding activity of AG was found significant while insignificant with AG-A and AG-E. These findings indicate that AG and its extracts protect the gastric mucosa against indomethacin-induced gastric changes, may result, from their antioxidant effect, which inhibits lipid peroxidation.

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