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Journal of Biological Sciences
Year: 2003  |  Volume: 3  |  Issue: 10  |  Page No.: 875 - 881

Effect of Chloroquine on Blood Glucose and Cholesterol Levels in Alloxan-induced Diabetic Rabbits

F.O. Obi, H.C.C. Maduka and Y.P. Mamza    

Abstract: The effect of treatment with chloroquine and normal saline on blood glucose and serum cholesterol levels was investigated in alloxan-induced diabetic and non-diabetic rabbits. It was observed that high dose of chloroquine (25 mg kg‾1 body wt) administration twice daily for three consecutive days led to an increase in the blood glucose and decrease in the serum cholesterol levels. The possible mechanism for the hyperglycaemic and hypocholesterolemic effects being observed was x-rayed in the light of other reported observations of chloroquine administration.

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