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Journal of Biological Sciences
Year: 2003  |  Volume: 3  |  Issue: 3  |  Page No.: 298 - 304

Anionic Hydrogels for Controlled Release of Transdermal Drug

Bashir Ahmad, Shumaila Bashir, Muhammad Nisar and M.B.Huglin    

Abstract: Anionic hydrogels, using Azo-iso butyronitrile as cross linker, with varying ionic moieties were prepared from N vinyl-2-Pyrrolidone/Methylene Succinic acid/water by heating them at different temperatures for different interval of times. Swelling/drug loading sensitivity with pH and ionic strength of the medium for these hydrogels were investigated. The results anticipate that hydrogels in the ratio of VP/IA 90:10 can be used for local therapeutic Transdermal drug delivery application of cationic, antifungal terbinafine hydrochloride (TER-HCl) in the concentration range of <100 mg ml G 1. In vitro studies in different buffer solutions indicated that pH and IA contents are two basic parameters which affect the release behaviour of the hydrogels.

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