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Journal of Animal and Veterinary Advances
Year: 2013  |  Volume: 12  |  Issue: 4  |  Page No.: 504 - 508

Immunogenicity and Protective Efficacy of a Attenuated Salmonella-Vectored Vaccine Expressing Esat6 Against Tuberculosis in Mice

Shi Wang, Yuan Di and Xudong Liu    

Abstract: It is a need to develop protective vaccines against Tuberculosis (TB) that elicit full immune responses including mucosal immunity. Here an attenuated Salmonella-vectored vaccine expressing Esat6 of the Mycobacterium tuberculosis (Mtb) were constructed. These vaccine were assessed for their immunological efficacy on Specific Pathogen-Free (SPF) mice challenged with Mtb. The experimental data demonstrated that this SL(E6) vaccine and BCG could induce the stronger TB Ag-specific mucosal, humoral and cellular immune responses and exerted high protective efficacy in mice against virulent Mtb H37Rv challenge compared to the other vaccinated groups (mice immunized with Esat6, a DNA vaccine or BCG only). These data may represent a novel promising Salmonella vaccine candidate for the prevention of TB.

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