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Journal of Animal and Veterinary Advances
Year: 2012  |  Volume: 11  |  Issue: 7  |  Page No.: 988 - 994

Effects of Grain Larvae Extracts on Hepatotoxicity and Blood Lipid in Obese Rats

Park Byung-Sung and Park Sang-Oh    

Abstract: The purpose of this study was to evaluate the effect of the ethanol extract from the grain larvae (GLE: Grain Larvae Ethanol extract) on the blood lipid level of high-fat diet-induced obese rats (Experiment I) and on the protective effect of liver damage in rats that were given intraperitoneal injections of Chlorotetracycline (CCl4) and alcohol (Experiment II). For Experiment I, 27 male rats (SDS strain) were randomized into three treatment groups: NC (Normal Control group fed with chow diet without the administration of GLE), HO (High-fat diet induced Obese group) and HOE (High-fat diet induced Obese rats administered orally with GLE 5.0 mg/100 g body weight). For Experiment II, 45 male rats (SDS strain) were randomized into five treatment groups: T1 (control group), T2 (intraperitoneal injection of CCl4), T3 (oral administration of GLE combined with intraperitoneal injection of CCl4), T4 (combined administration of GLE and alcohol) and T5 (intraperitoneal injection of alcohol combined with oral administration of GLE). Compared with HO, the levels of triglyceride, total cholesterol and LDL-cholesterol in blood decreased significantly in HOE while the HDL-cholesterol level showed a significant increase (p<0.05). Concentrations of AST, ALT, γ-GTP and bilirubin in blood significantly decreased in T3 and T5 groups with oral administration of GLE, compared with T2 and T4 groups (p<0.05). In rats in T3 and T5 groups, recovery of liver tissue cells from damage that had been induced by intraperitoneal injections of CCl4 (T2) and alcohol (T4) could be observed.

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