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Journal of Animal and Veterinary Advances

Year: 2012  |  Volume: 11  |  Issue: 15  |  Page No.: 2672 - 2676

Clinicopathological Effects of Various Levels of Dietary Ambrosia maritima on Wistar Rats

S.E.M. Barakat, F.A. Al-Hizab and A.O. Bakheit

Abstract

The present study deals with the clinicopathological and biochemical effect of A. maritima on male Wistar rats. Ambrosia maritime is claimed to have several medicinal properties and used as a traditional medicine for the treatment of various disorders. The plant was fed to rats at 2 and 10% of the standard diet for 4 weeks. A 2% A. maritima was not toxic to rats during the experiment. However, mild increase in body weight, fatty cytoplasmic vacuolation, centrolobular individual cell necrosis and mild enteritis were observed in rats fed a diet containing 10% A. maritima. These findings were accompanied by alteration of serum Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and no changes were observed in the activities of ALP, concentrations of total protein, urea, total bilirubin, HDL and LDL. The concentrations of cholesterol and glucose were significantly decreased in the serum of rats fed 2 and 10% A. maritima.

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