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Journal of Animal and Veterinary Advances

Year: 2012  |  Volume: 11  |  Issue: 14  |  Page No.: 2445 - 2452

Effect of Aloe vera on Healing of the Experimental Skin Wounds on Rats and its Comparison with Zinc Oxide: A Geometry and Histopathologic Study

Ali Rezaie, Amirreza Ebadi, Mehrdad Nazeri, Samad Rezaie and Fatemeh Elmi


Aloe vera is a perennial succulent belong to the Lily (Liliaceae) family. This plant has been known as the healing plant. Aloe vera has been used for traditional medical purposes in several cultures for millennia. It has been demonstrated that Aloe vera has growth promoting activities. The objective of this study was to determination of the effect of Aloe vera on healing of the experimental skin wounds on rats and its comparison with zinc oxide. Zinc oxide is being used worldwide as an absorbent and protective compound. Its pharmacological properties are wide and its non-toxic material allows it to be used as a routine skin care substance. In current study, 70 female wistar rats where included in 5 groups. Full thickness incisional wound with 23 mm diameter was made with surgical scissors and scalpel. The whole operation was taking place under general anesthesia and analgesia circumstances. After making surgical wounds, rats are treated as mentioned in the text. Rats are observed for 21 days for wound closure process and inflammatory conditions taking place in wound. Biopsy intervals are 0 (the day of surgery), 3, 7, 14 and 21th day after surgery. In these certain days rats were euthanized and biopsies of wound sites were obtained. Wounds areas are also, measured by Scion Image ™ Software daily. At last, all data were analyzed using SPSS Statistics Ver.17. As a result, Aloe vera at the dose of 10% has significant healing properties compared to Zinc oxide. These data were validating under confidence surface of 95% (p<0.01).