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Journal of Animal and Veterinary Advances
Year: 2012  |  Volume: 11  |  Issue: 12  |  Page No.: 2143 - 2147

Study of Sedation, Pre-Anesthetic and Anti-Anxiety Effects of Celandine Extract Compared with Diazepam in Rats

Ali Rezaie, Arash Pezeshki, Behzad Zadfattah, Mehrdad Nazeri, Changiz Ahmadizadeh and Babak Mohammadi    

Abstract: Celandine with scientific name Chelidounium majus, spreads across the world and exists in Northern parts of Iran like Gilaan, the outskirts of Rasht, Roodbar and Mazandaran. Some of effective chemical compounds are: malic, copticine, cityicacid, chelerythrine, berberine, succinic acid and sangainarine acid. The herb’s other medical properties are: calmative, narcotic, anti spasm, lowering blood pressure, antibilious, cathartic and wormroot in internal uses. Epispastics and flesh wound amneliorator in external uses. Other chemical compounds of the herb have alkaloids that some of which are toxic those alkaloids are Chelidtine hemochelidotine, cheleritrine, sangainarine and protopine. In the present study, 30 Wistar male rats of 200-230 g weight and about 3 months old were used for laboratory experiments. Animals were kept in standard condition, at 20-25°C, 70% humidity and light cycle of 12 h lighting and 12 h darkness. Standard plates were used in order to feeding by method of ad-libitum, i.e., 24 h feeding. It can be concluded, generally that based on different studies the extract of celandine may affect via effecting on benzodiazepine receivers connected to GABA receivers (considering its flavonoid content). Based on the obtained results by the present study it can be said that according to sedation process the extract dosage of 400 mg kg-1 BW among other dosages has had more meaningful results and has a better sedation, pre-anesthetic and anti-anxiety effects compared with diazepam (p<0.01).

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