Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Journal of Animal and Veterinary Advances
Year: 2011  |  Volume: 10  |  Issue: 4  |  Page No.: 480 - 483

Expression of Augmenter of Liver Regeneration and Nuclear Faction-κB in Human Hepatocellular Carcinoma

Zhang Aimin and Shen Shiqiang    

Abstract: To determine whether the levels of expression of the Augmenter of Liver Regeneration (ALR) and nuclear faction-κB(NF-κB) were assoiated with the clinicopathological features in human Hepatocellular Carcinoma (HCC). Gene expression was measured by using RT-PCR in the 30 human HCC tissues, matched adjacent tissues and 8 normal hepatic tissues. The clinicopathological data of all patients were also collected. Higher expression of ALR mRNA was observed in HCC tissues compared with normal liver tissue (p<0.05), it did not differ from the expression of matching non-neoplastic tissue in the same patient (p>0.05). Expression of both two genes were not found to be significantly associated with clinical/pathologic factors. (p>0.05). The expression of ALR mRNA in HCC tissues was positively correlated with NF-κB mRNA (r = 0.382, p<0.05). Up-regulation of ALR may play partial role of carcinogenesis through MAPK pathway in HCC.

Fulltext    |   Related Articles   |   Back
  Related Articles

Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility