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Journal of Animal and Veterinary Advances
Year: 2011  |  Volume: 10  |  Issue: 15  |  Page No.: 1917 - 1921

Expression Profiling of MYOZ1 Gene in Porcine Tissue and C2C12 Cells

Yin Liu, Ke Zhou, Xin-Yun Li, Shu-Hong Zhao and Jian-Hua Cao    

Abstract: The structure and function of Z-discs were related strongly to the normal physiological phenotype and function of skeletal muscle. The protein Myozenin (MYOZ), an α-actinin and γ-filamin-binding Z-disc globular protein expressed predominantly in skeletal muscle was possibly involved in the confirmation and function of Z-discs. Here we described MYOZ1 gene which has a significantly higher expression level in skeletal muscle than several other tissues in porcine. Furthermore, MYOZ1 transcripts in three porcine development stages (embryonic 33 days, embryonic 65 days and adult) of skeletal muscle shown stepwise increasingly expression pattern by using quantitative PCR analysis. Functional assays were conducted using C2C12 cells and the results implied MYOZ1 was not involved in both of cellular proliferation and differentiation.

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