Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Journal of Animal and Veterinary Advances
Year: 2010  |  Volume: 9  |  Issue: 4  |  Page No.: 848 - 852

Pharmacokinetics of Cefquinome in Camels

A.Y. Al-Taher    

Abstract: The Pharmacokinetic characters of cefquinome were studied in camels following single intramuscular administration of 1 mg kg-1 b.wt. Cefquinome concentrations in serum were determined by microbiological assay using Micrococcus luteus (ATCC 9341) as test organism. After intramuscular administration, the mean peak serum Concentrations (Cmax) was 1.23 μg mL-1 and achieved after (tmax) 4.25 h. The absorption half life (tl/2(ab)) was 4.35 h and the elimination half-life (tl/2(el)) was 10.24 h. The Mean Residence Time (MRT) was 16.74 h and area under curve from zero time to infinity (AUC0-∞) was 20.37 μg/mL/h. The serum concentrations of cefquinome along 24 h post-injection in this study was exceeding the MICs of different susceptible micro-organisms responsible for serious disease problems. These findings indicate the suitability of successful use of this antibiotic in camels. A recommended single daily dose of 1 mg kg-1 of cefquinome given intramuscularly can achieve quite therapeutic concentrations in serum, that exceeding the minimal inhibitory concentrations against different susceptible pathogens.

Fulltext    |   Related Articles   |   Back
 
 
   
 
 
 
  Related Articles

 
 
 
 
 
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility