Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Journal of Animal and Veterinary Advances
Year: 2010  |  Volume: 9  |  Issue: 10  |  Page No.: 1441 - 1444

A Polymorphism in the IFN-γ Gene is Associated with Immune Response and Economic Traits in Landrace Pig

Nu-Nu Sun, Hui-Yong Chen, Xiang-Dong Liu, Ming-Di Fang, Shu-Hong Zhao and Zhen-Fang Wu    

Abstract: Interferon-gamma (IFN-γ) is essential for modulating immune responses in mammals. In this study, one Single Nucleotide Polymorphism (SNP) of porcine IFN-γ (Po IFN-γ) was identified at position 1165 in intron I (deletion or insertion of A). Blood samples from 306 piglets were collected. The blood parameters, antibody levels of PRRSV, CSFV and PRV were measured for all piglets at 1, 17, 32 days ages, respectively. In addition, 11 growth traits were also measured for all pigs. Association analysis between the IFN-γ- + 1165 + A polymorphism and antibody levels, blood parameters and growth traits were conducted. Significant effects of the SNP genotype was observed on 1st day PRV Ab, muscle depth (p<0.01), 1st day CSFV Ab, 32nd day MCHC, hucklebone width and daily gain from birth to 100 kg (p<0.05). Thus, the single nucleotide deletion polymorphism in IFN-γ could be an important genetic marker for both immune response and growth traits and can be potentially used in pig breeding.

Fulltext    |   Related Articles   |   Back
 
 
   
 
 
 
  Related Articles

 
 
 
 
 
 
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility