Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Journal of Animal and Veterinary Advances
Year: 2009  |  Volume: 8  |  Issue: 11  |  Page No.: 2256 - 2261

Melatonin Increases the Expression of Insulin-like Growth Factor I in Rats with Carbontetrachlorid-Induced Hepatic Damage

Jale Oner, Ilter Kus and Hakan Oner    

Abstract: The purpose of this study was to investigate, whether or not melatonin has a role in the prevention of CCl4-induced hepatotoxicity in rat by means of IGF expression. The animals used in study were grouped as following: Control, CCl-4 injected group and CC4 + melatonin injected group. Tissue samples were examined using immunohistochemistry and obtained data were evaluated statistically. IGF-I expression observed in hepatocytes was weakest in CCl4 injection group. Melatonin administration increased IGF-I expression in hepatocytes. The HSCORE value of the CCl4 injected group was lower than that of other groups. The highest HSCORE value belonged to CCl4 + melatonin injected group. On the basis of the data in the present study, we suggest that melatonin secreted by the pineal gland may have preventative role in hepatic damage by increasing IGF-I releasing.

Fulltext    |   Related Articles   |   Back
 
 
   
 
 
 
  Related Articles

 
 
 
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility