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Journal of Animal and Veterinary Advances
Year: 2008  |  Volume: 7  |  Issue: 8  |  Page No.: 991 - 995

The Humoral Immun Response of Mice to Liposomes Containing Brucella melitensis Outer Membrane Fragments

Fatma Kaynak Onurdag, Tuncer Degim, Zelihagul De im, Ismail Kutlu, Ozgur Kaynar, Gulsen Gunes and Ufuk Abbasoglu    

Abstract: Brucellosis is an important zoonotic disease and the prevention is made by vaccination of animals. For ewes Brucella melitensis REV-1 live attenuated vaccine is widely used but because of some risks such as being infected during the vaccination, re-infection of animals, a new vaccine with less side effect is need to be improved. In this study it was aimed to determine a strong humoral immune response by encapsulating the Brucella outer membrane antigens with the optimum liposome formulation and the statistical analyses showed that the Brucella outer membrane extract encapsulated with liposome can evoke humoral immune response better than live attenuated B. melitensis REV-1 vaccine in mice.

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