Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Journal of Animal and Veterinary Advances
Year: 2007  |  Volume: 6  |  Issue: 4  |  Page No.: 569 - 575

Induction of Fever and Sickness Behavior in Telemetrically Monitored Rats During Systemic Inflammation Induced by Zymosan

Thomas Hubschle, Sandra Rafalzik, Rudiger Gerstberger and Joachim Roth    

Abstract: Zymosan (Zy) has been shown to act as a pathogen-associated molecular pattern that activates the innate immune Toll-like receptor subtypes 2 and 6 (TLR2, TLR6). Systemic challenge with TLR2/6-agonists has been shown to mediate brain-controlled signs of sickness behavior amongst them fever, depressed motor activity, anorexia and adipsia. This study was designed to determine whether Zy as a further TLR2/6-agonist is also capable to induce similar sickness behavior responses during systemic Zy-induced inflammation as those observed with Mycoplasma-specific TLR2/6 agonists. In telemetrically monitored rats intraperitoneal treatment with 10 mg kg 1 Zy induced a moderate febrile response with significantly elevated abdominal temperatures ( T of about 1.2C) for a period of about 4 h on the day of injection (day 1). Already at the end of day 1 temperature data of the Zy group returned to normal values of control animals and thereafter showed an almost identical circadian rhythm for the next 3 nights and 2 days. Zy-treated animals showed generally lower cumulative motor activities, however, significantly reduced only during night 1 and night 3. Cumulative food intake was significantly reduced during night 1 and night 2 in the Zy group, while no significant changes were measured for cumulative water intake. In line with the depressed food intake, Zy-treated rats developed a reduction in body weight gain that became significant on day 3 and day 4 after the injection. In conclusion, Zy-induced fever, anorexia and depressed motor activity seem to result from activation of cellular pathways involved in the TLR2/6-dependent innate immune responses.

Fulltext    |   Related Articles   |   Back
   
 
 
 
  Related Articles

 
 
 
 
 
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility