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Journal of Animal and Veterinary Advances
Year: 2007  |  Volume: 6  |  Issue: 2  |  Page No.: 267 - 271

Systemic Effects of Sildenafil Citrate on Pregnancy and Perinatal Periods

P. Sanchez-Aparicio, D. Mota-rojas, R. Ramirez Necoechea, A. Olmos-Hernandez, M. Alonso-Spilsbury, D. Villanueva-Garcia, M.E. Trujillo-Ortega and R. Hernandez-Gonzalez    

Abstract: Sildenafil citrate is an orally administered effective treatment for erectile dysfunction; nevertheless administrated in high concentrations produces relaxation of myometrium in pregnant women, thus sildenafil or related molecules may have future potential tocolytic application. In the present review sildenafil mechanism of action, pharmakocinetics and therapeutic use are discussed. Sildenafil is also considered a potent pulmonary vasodilator in pharmacology representing an alternative to neonates during the last month of in utero development. We conclude that studies in animals including metabolic and physiological traits in the fetus and neonates from treated dams with sildenafil in their last third of pregnancy may help to characterize neonate tolerance to asphyxia with posterior application in human perinatology.

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