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Journal of Animal and Veterinary Advances

Year: 2005  |  Volume: 4  |  Issue: 1  |  Page No.: 46 - 50

Evaluation of Cytoprotection Against Ethanol-induced Injury in Gastric Mocosa Pretreated with Honey Alone, Honey in Combination with Ocimum bacilicum Oil or Honey in Combination with Cimetidine in Rats

Mahmood, A.A, K. Sidik, U.R. Kuppusamy, K.A.R.Suzainur, M.Indran and I. Salmah


Honey alone or, honey in combination with O. bacilicum oil or with cimitidine was found to posse`s significant anti-ulcer activity against ethanol-induced ulceration in experimental animal models macroscopically and microscopically. Significant inhibition was observed against ethanol-induced ulceration. Macroscopically, oral administration of absolute ethanol (5 ml kg-1 body weight) to fasted rats produced extensive hemorrhagic lesions of gastric mucosa. Pretreatment with honey alone (5 ml kg-1 body weight) or honey in combination with O. bacilicum oil extracts (5 ml kg-1 body weight) or honey in combination with cimitidine (5 ml kg-1 body weight) orally 30 minutes before administration of absolute alcohol significantly prevent or reduced the formation of such lesion. Microscopically, pretreatment rats showed significantly marked inhibition or reduction of gastric damage and no submucosal edema or leucocytes infiltration.