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Journal of Animal and Veterinary Advances
Year: 2005  |  Volume: 4  |  Issue: 2  |  Page No.: 221 - 223

Comparative Efficacy of Neem and Karela with Insulin and Glibenclamide on Biochemical Parameters in Rabbit

S. Ahmed, M. A. Awal, M. M. Rahman and M. Mostofa    

Abstract: Comparative efficacy of neem and karela with insulin and glibenclamide was studied on some biochemical parameters (Blood glucose, Serum urea and Serum creatinine) in 40 rabbits from February to April, 2003. Rabbits were randomly divided into 8 equal groups and rabbits of group A and B were kept as non hyperglycemic control and hyperglycemic control respectively. Hyperglycemia was induced in 7 groups of rabbits (B, C, D, E, F, G and H) by administering alloxan at a dose of 200 mg/ kg body wt. s/c. After 15 days of alloxan injection, 6 groups of rabbits (C, D, E, F, G and H) were treated with insulin, glibenclamide, neem seed kernel powder (NP), neem seed oil (NSO), neem leaf extract (NLE) and karela fruit juice (KFJ) at the dose rate of 5 U/kg, 0.5 mg/ kg., 500 mg/kg , 1 ml/kg , 500 mg/ kg.and 100 mg/kg body weight respectively for consecutive 28 days. All the control and treated rabbits were closely observed during 28 days of treatment and also for 14 days of post-treatment period and biochemical parameters were investigated. Blood glucose levels were significantly (P<0.01) reduced in all treated six groups of rabbit to the extent of 25-42% in comparison to their pre-treatment values. Similarly, serum urea and creatinine values were reduced significantly (P<0.01) to the extent of 15-25% and 4-15% respectively on 28th day of treatment in comparison to their 21th day treatment values. It was also observed that patent drugs insulin and glibenclamide induced better and almost equal efficacy in reducing the parameters whereas herbal preparations of neem, i.e., NP, NSO and NLE showed almost equal but less efficacy than two patent drugs and Karela fruit juice was found to be least effective. It may be concluded that instead of less efficacy than patent drugs, the efficacy of neem and karela was also encouraging.

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