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Journal of Applied Sciences
Year: 2018  |  Volume: 18  |  Issue: 2  |  Page No.: 65 - 70

Nanoparticles Effects on Zinc Oxide/green Tea Complex on the Lipid Profile and Liver Functions of Rats after Monosodium Glutamate Treatment

Reham Z. Hamza, Fawziah A. Al-Salmi and Nahla S. El-Shenawy    

Abstract: Background and Objective: The potential benefit of green synthesis zinc oxide nanoparticles (ZnO NPs) is still a deprecatory issue. The aim of the present research was to elucidate the anti-hyperlipidemia of green tea leaves extract (GTE)/ZnO NPs complex against monosodium glutamate (MSG). Materials and Methods: Eight different groups of male rats were used: Group I was the control, group II received GTE (1 mg mL–1), group III was treated with ZnO NPs (10 mg kg–1), groups IV and V received MSG in two different doses (6.0 and 17.5 mg kg–1), group VI treated with ZnO NPs/GTE complex, groups VII and VIII were given ZnO NPs/GTE complex plus MSG in different doses. The effect of ZnO NPs/GTE complex against MSG toxicity through studying the alteration of enzyme activity of liver functions [alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alkaline phosphatase (ALK) and γ-glutamyl transferase (γ-GT)] and lipid profile alternation have been described. The rats that were given MSG only had a highly significant elevation in liver enzymes and severe lipid metabolism changes. Results: The findings for group VII and VIII clarify the efficacy of ZnO NPs/GTE complex as a hepato-protectant on MSG alone through improving the liver enzyme activity along with the lipid profile. The activities of ALT, AST, LDH, ALP and γ-GT in the serum were significantly reduced. Conclusion: ZnO NPs/GTE complex was proved to be a potential hepatoprotective as it significantly ameliorates the hepatotoxicity induced by MSG through hyperlipidemia reducing effect.

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