Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Journal of Applied Sciences
Year: 2012  |  Volume: 12  |  Issue: 3  |  Page No.: 263 - 270

Preparation of Surfactant-free Linear and Star-shaped Poly(L-lactide)-b-methoxy Polyethylene Glycol Nanoparticles for Drug Delivery

Yodthong Baimark    

Abstract: The objective of this research was to investigate the effect of arm number of Poly(l-lactide)-b-methoxy poly(ethylene glycol) (PLL-b-MPEG) amphiphilic diblock copolymers on their characteristics of drug-loaded nanoparticles and in vitro drug release. Linear and star-shaped PLL-b-MPEG diblock copolymers were synthesized via the ring-opening polymerization of L-lactide followed by coupling reaction with a monofunctional carboxyl end-group MPEG. These diblock copolymers included linear copolymer having one arm and star-shaped copolymers having four and six arms. The crystallinity of MPEG block within diblock copolymers was suppressed. The melting point (Tm) and degree of crystallinity (χc) of PLL block within diblock copolymers decreased as the arm number increased. Drug-loaded nanoparticles of these copolymers were prepared by the emulsification-diffusion method under surfactant-free condition. Indomethacin was used as a poorly water-soluble model drug. The nanoparticles with less than 200 nm in size were nearly spherical shape. Different arm numbers did not affect average size and drug loading efficiency. However, the Tm and χc of diblock copolymers slightly decreased after drug loading. From in vitro drug release test, drug release content increased steadily as the arm number increased.

Cited References   |    Fulltext    |   Related Articles   |   Back
  Related Articles

Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility