Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Journal of Applied Sciences
Year: 2009  |  Volume: 9  |  Issue: 3  |  Page No.: 555 - 560

Identification of Ionic Conductances in a Reentry Model of Ventricular Myocardium Cells

Z.S. Dastgheib, A. Azemi, M. Khademi, M. Shajiee, M. Arvaneh, H. Gholizadeh and V.R. Sabzevari    

Abstract: In this study, a new method will be introduced to find ionic conductance parameters of ventricular cell channels that are part of a reentry loop. These parameters play a significant role in generation and dispersion of a normal action potential and hence ECG signal and formation of a reentry. The dangerous phenomenon reentry, occur when an electrical impulse travels in a circle within the heart, rather than moving outward and then stopping. Depending on the timing, this can produce a sustained abnormal rhythm, a self-limiting burst of supraventricular tachycardia, or a dangerous ventricular tachycardia. Here, a detailed Luo-Rudy model has been used for modeling ventricular myocardium cells and construction of a one-dimensional ring for reentry simulations. The proposed method is based on using Genetic Algorithms to identify the unknown parameters. The advantage of the proposed method over Least Squares parameter estimation approach is provided.

Cited References   |    Fulltext    |   Related Articles   |   Back
  Related Articles

Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility