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Journal of Applied Sciences

Year: 2009  |  Volume: 9  |  Issue: 19  |  Page No.: 3593 - 3597

Prevalence of BRAFV600E Mutation in Iranian Patients with Papillary Thyroid Carcinoma: A Single-Center Study

J. Mohammadi-Asl, B. Larijani, Z. Khorgami, S.M. Tavangar, V. Haghpanah and P. Mehdipour

Abstract

The aim of this study was to investigate the frequency of the BARFV600E mutation in Papillary Thyroid Carcinoma (PTC) in Iranian population through PCR-RFLP. Fifty formalin-fixed paraffin-embedded and 26 frozen thyroid tumors including 28 PTCs, two undifferentiated thyroid carcinoma and 46 benign thyroid tumors were evaluated. The BARFV600E mutation was detected in 20 of 28(71.4%) PTCs, but failed to distinguish the mutant allele in benign thyroid tumors. The age, sex, extrathyroid extension and lymph node metastases distribution did not, significantly, differ between the patients with and without the BARFV600E mutation. In conclusion, these findings might pave our way towards considering the BRAFV600E mutation in PTCs in the regions with high prevalence of this alteration as a molecular marker.

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