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Journal of Applied Sciences
Year: 2008  |  Volume: 8  |  Issue: 1  |  Page No.: 158 - 162

Synthesis of Dihydropyridine Analogues for Sperm Immobilizing Activity

H.R. Sadeghipour Roodsari, M. Amini, Z. Naghibi Harat, P. Daneshgar, M. Vosooghi and A. Shafiee    

Abstract: In the present study, the activity of seven newly synthesized dihydropyridine analogues on the motility of sperm were determined and compared to nifedipine activity that was used as standard. Sperm motility reduced value for test compounds 6a-g shows a gradual increase proportional to the size elongation of alkyl ester groups. Consequently the size of alkyl is important in the activity of test compounds and finally increase in the lipophil size of hydrocarbon`s ester (R1) is inversely related to the activity of the synthetic compounds. As a result, the methyl ester of the test compounds with 50% of nifedipine activity (in two hours group) is the most active test compound.

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