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Journal of Applied Sciences
Year: 2007  |  Volume: 7  |  Issue: 21  |  Page No.: 3322 - 3325

Deterioration of Parabens in Preserved Magnesium Hydroxide Oral Suspensions

Pirali Hamedani Morteza, Fazeli Mohamad Reza, Samadi Nasrin, Nassireslami Ehsan, Rezazadeh Shams Ali and Mohsen Amini    

Abstract: In this study the chemical stability of methyl and propyl paraben in magnesium hydroxide suspension (pH about 10) was investigated using both real time (32 months incubation at 25±2°C with humidity of 60±5% RH) and also accelerated (3 months incubation at 40±2°C with humidity of 70±5% RH) methods. Preparation with no added preservative was used as control. Concentrations of methyl and propyl paraben decreased to levels lower than the reported MIC values after the first month and fifth months of real time study, respectively. Preservative effectiveness testing against the Pharmacopeal challanging microorganisms in both suspensions with or without parabens conformed the US Pharmacopeia requirements for oral antacids. It is concluded that alkaline pH of the suspension without parabens could preserve the product against Pharmacopeial challenging microorganisms and incorporation of parabens did not add any antimicrobial activity to the test product.

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