Abstract: According to the Hefei subway deep foundation pit engineering, this study expounds the pile-anchor supporting scheme of prestressed anchor cable layout optimization. Combined with the actual situation of engineering, numerical simulation was carryed out by using FLAC3D software. The four different layout of prestressed anchor cable is used for simulation analysis, Detailed to carry out the horizontal displacement of the pile and anchor axial force analysis, discuss the anchor cable layout optimization. Calculation results provide a reference for support scheme of similar large deep foundation pit.