Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
International Journal of Zoological Research
Year: 2009  |  Volume: 5  |  Issue: 2  |  Page No.: 42 - 61

Anti-hyperglycemic, Immunomodulatory and Anti-oxidant Efficacy of Vasoactive Intestinal Peptide in Streptozotocin-Induced Diabetic Mice

O.M. Ahmed    

Abstract: The purpose of this study was to assess the effects of vasoactive intestinal peptide (VIP) administration on the glycemic state, insulin secretion, various pro-inflammatory and anti-inflammatory cytokines, liver pathology and oxidative stress as well as antioxidant defense system in streptozotocin-induced diabetic mice. VIP was intraperitoneally administered to normal and streptozotocin-induced diabetic CD1 mice at a dose level of 41.6 ng kg-1 b.wt., 3 times/week for 8 consecutive weeks to form a total dose of 1 μg kg-1 b.wt. at the end of the experiment. The VIP was found to have anti-hyperglycemic and insulinotropic properties and improving effects on the islets of Langerhans and liver pathology of diabetic mice. These VIP ameliorating-changes may be mediated via its augmenting effect on anti-inflammatory cytokines (IL-10 and IL-12) and decreasing effect on pro-inflammatory cytokine, TNF-α, as well as its potency in suppressing the oxidative stress and enhancing the anti-oxidant defense system. However, further clinical studies are required to assess the efficacy and safety of VIP in diabetic human beings.

Cited References   |    Fulltext    |   Related Articles   |   Back
  Related Articles

Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility