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International Journal of Tropical Medicine
Year: 2006  |  Volume: 1  |  Issue: 2  |  Page No.: 88 - 92

Effect of a Polyherbal Formulation (Diarun plus) on Streptozotocin Induced Experimental Diabetes

G. Senthilvel, M. Jegadeesan, Anoop Austin, P. Thirugnanasambantham, E. Mayisvren, M. Balasubramanian, N. Narayanan and S. Viswanathan    

Abstract: Diarun plus was evaluated for its therapeutic antihyperglycemic activity in streptozotocin-induced diabetes in animal models. It was effective in controlling hyperglycemic status in rats and mice. The drug (500 mg/kg) showed significant antidiabetic property as judged by serum glucose levels. However, it did not significantly influence the levels of serum insulin in both diabetic and normoglycemic rats. This is a promising drug to develop standardized phytomedicine for diabetes mellitus. The findings suggest that it can be considered as a therapeutic agent, wherever elevated glycemic status is observed.

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