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International Journal of Pharmacology

Year: 2022  |  Volume: 18  |  Issue: 4  |  Page No.: 673 - 681

Acute Toxicity Studies and Psychopharmacological Effects of Eucalyptus globulus Leaf Oil in Rodents

Muhammad Afzal, Imran Kazmi, Sami I. Alzarea, K.K. Sharma, Chetan Kumar Dubey, Piyush Mittal, Anurag Verma, Arinjay Jain and Ali Alquraini


Background and Objective: Stress is described as a physically or mentally change that affects the organism's homeostatic and balance and is considered to cause 75% of all diseases. The E. globulus trees leaf oil polyherbal formulation was evaluated for its antistress activity in the present experiment. Material and Methods: The study employed Wister rats weighing 150-200 g for toxicity testing and Albino mice weighing 15-25 g for the investigation. Acute toxicity studies were carried out for pure essential oil of Eucalyptus globulus following (OECD guideline 423, 2001). The rats were split into 2 groups, each with 3 male rats (n = 3). The experimental group received EOE in an oral dose of 2000 mg kg–1 body weight. Adult male albino mice approximately 20-25 g. were selected for anti-stress testing and split into 5 groups, each with 5 animals. Three activities were selected. FST, TST and anoxia stress tolerance test model, animals were treated with three doses of EOE (100, 200, 400 mg kg–1, p.o). Results: Findings of acute toxicity studies suggested no major toxicity, results for assessment of antistress influences showed that administration of eucalyptus leaf oil at mentioned doses decreases immobility times when compared with control. In the same way, animals treat with diazepam (1 mg kg–1) as predictable, show a major decrease in the immobility time. Conclusion: The current study investigation discovered that eucalyptus oil show antistress activity by preventing stress-induced by FST, TST and anoxia stress tolerance test model.

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