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International Journal of Pharmacology

Year: 2022  |  Volume: 18  |  Issue: 7  |  Page No.: 1509 - 1520

Europinidin Enhances Healing through Modulating Antioxidant Processes in Experimentally Induced-Stomach Ulcer Condition

Muhammad Afzal, Khalid Alharbi, Sattam Alenezi, Mohammed Alshammari, Fadhel Alomar and Imran Kazmi

Abstract

Background and Objective: Anthocyanidin, a flavonoid generated from plants, has a wide spectrum of therapeutic benefits, according to research. Europinidin is a natural water-soluble pigment derived from delphinidin, an anthocyanidin with an O-methyl ring. In this study, the anti-ulcerative properties of flavonoids were assessed using an experimental animal model of ethanol-induced stomach ulcers. Materials and Methods: In an experimental rat model, the therapeutic effectiveness of flavonoid 10 mg kg1 was investigated using a 10 days procedure for pharmacological evaluation ulcer score, pH, total acidic content and biochemical markers such as superoxide dismutase (SOD), catalase activity (CAT), glutathione (GSH), myeloperoxidase (MPO), malondialdehyde (MDA), Tumour Necrosis Factor-α (TNF-α), nitric oxide (NO) and prostaglandin E2 were all investigated. Results: When compared to the control cluster of ethanol, stomach parameters such as ulcer score, pH and acidic content were maintained in the flavonoid clusters. In comparison to the normal cluster, gastric ulcers have a considerable rise in serum levels, GSH, SOD and CAT as well as a decrease in MDA, TNF-α and prostaglandin E2 characteristics. In the test clusters, flavonoids significantly improved all serum parameters. Conclusion: The results of this study showed that it is possible to produce cost-effective phytochemical alternatives for the treatment of chemically generated stomach ulcers.

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