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International Journal of Pharmacology
Year: 2019  |  Volume: 15  |  Issue: 7  |  Page No.: 880 - 890

Anti-arthritic Effect of Baicalein Exert on Complete Freund’s Adjuvant-induced Arthritis in Rats by Reducing the Inflammatory Reaction

Guiyun Huang, Tonggeng Guan, Peng Wang and Shourong Qin    

Abstract: Background and Objective: Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affected the joints. The aim of the current study was to investigate the anti-arthritic and anti-inflammatory effect of baicalein against complete Freund’s adjuvant-induced arthritis via alteration of inflammatory reaction. Materials and Methods: Complete Freund adjuvant (CFA) was to induce arthritis in the Wistar rats and rats were divided into a different group and received the oral administration of baicalein until 28 days. The paw edema, body weight and arthritic score were estimated at a regular time interval. At the end of the experimental period, antioxidant, hematological and pro-inflammatory cytokines were estimated. Results: Baicalein treated rats showed the down-regulation of paw edema, arthritic score and significantly (p<0.001) increased the body weight. Baicalein treatment significantly (p<0.001) modulated the antioxidant, hematological parameters and pro-inflammatory cytokines. Baicalein attenuated the effect of CFA on bone surface area, bone volume and trabecular thickness. Baicalein significantly (p<0.001) reduced the inflammation, cartilage surface erosion, chondrocyte death and bone erosion. Conclusion: Baicalein indicated the beneficial effect against the CFA induced arthritic rats via pro-inflammatory cytokine mechanism.

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