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International Journal of Pharmacology
Year: 2019  |  Volume: 15  |  Issue: 7  |  Page No.: 837 - 843

Synergistic Effect of Asiatic Acid and Madecassic Acid against Antioxidant Deficit in Rat Peripheral Nervous System

Peng Wang, Teng-Fei Long, Li-Ping Wang and Jie Song    

Abstract: Background and Objective: Epidemiological studies have shown admiring protective roles of phytochemicals on peripheral nervous system, while the prevalent use of hypotensive drugs directly impacts normal functioning of the nervous system. Hence, the present study was assessed the synergistic role of Asiatic Acid (AA) and Madecassic Acid (MA) against the antioxidant deficit induced by the metoprolol tartrate. Materials and Methods: Wistar male rats (150 mg kg1) were divided into 4 groups. Group 1 as control with no treatment, group 2 rats with metoprolol tartrate (150 mg kg1/day, orally), group 3 rats pre-treated with AA (50 mg kg1, IP) and MA (30 mg kg1, IP) for 2 weeks prior to metoprolol tartrate and group 4 with AA and MA combined as drug control for 28 days. Blood pressure (BP), heart rate (HR) and other antioxidant parameters were monitored and the blood samples were collected for endocrine and biochemistry analysis. Results: Metoprolol administration demonstrated a significant reduction in body weight, systolic BP, heart rate and food intake, while the levels of lipid peroxidation was increased significantly compared to control rats. Also, a significant decrease (p<0.01) in the antioxidant levels such as; SOD, catalase, glutathione peroxidase, reduced glutathione were evidenced in metoprolol group. On the other hand, the neuronal markers enzyme acetylcholinesterase were reduced while the activity of Nitric Oxide Synthase (NOS), Cytochrome P450 Reductase (CPR) and Carbonic anhydrase were increased in metoprolol group compared to control. However, rats received AA and MA pre-treatment elicited the improved antioxidant enzymes with restored physiological parameters, food intake and reduced the marker enzymes activity. Conclusion: The results of present study demonstrated the protective role of AA and MA against antioxidant deficit induced by the metoprolol tartrate by improving the physiological functions.

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