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International Journal of Pharmacology
Year: 2019  |  Volume: 15  |  Issue: 4  |  Page No.: 457 - 464

Modulation of Pro-inflammatory Mediators by Eugenol in AlCl3 Induced Dementia in Rats

Yanxin Zhao, Dong Wang, Souravh Bais and Hongxin Wang    

Abstract: Background and Objective: Alzheimer disease is one of the common types of dementia, which involves progressive neuronal cell's degeneration. The main objective of this study was to evaluate the in vitro anti-choline esterase activity of four phenyl propanoids derivatives (Eugenol, Gallic acid (GA), Sinapic acid and Scopolin) and evaluation of Eugenol in AlCl3 induced dementia in rats. Materials and Methods: The four phenyl propanoids derivatives (Eugenol, Gallic acid (GA), Sinapic acid and Scopolin) were evaluated for in vitro anti-choline esterase activity. For in vivo screening the rats were treated with aluminum chloride at a dose of 175 mg kg–1, for a period of 25 days to produce dementia. Then rats divided in 4 different groups and further evaluated for 10 days of treatment , i.e., Negative control, Standard group and one group received sub maximal dose of rivastigmine along with Eugenol (1.25 mg kg–1 p.o+ 50 mg kg–1 Eugenol, p.o) and other group received Eugenol (50 mg kg–1, p.o) alone. All rats were observed until the 35th day of experimental protocol. The different behavioral and biochemical parameters like GSH, TBARS and Nitrite level were also determined. Neuro-protective activity of eugenol against neuro inflammation produced by AlCl3 was accessed by estimations of two pro inflammatory cytokines (TNF-α, IL-1β) in brain tissues. Results: Rats treated with aluminum chloride (175 mg kg–1, p.o.) produced a significant decline in behavioral and biochemical parameters in rats. The rats treated with Eugenol showed significant reversal of memory deficit Dementia of AD type. Conclusion: The study concluded that Eugenol had a synergistic effect with rivastigmine when used in combination and showed neuro protection against AlCl3 induced dementia of AD type in rats and modulates the neuro inflammation produced by AlCl3.

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