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International Journal of Pharmacology
Year: 2019  |  Volume: 15  |  Issue: 1  |  Page No.: 102 - 109

Anti-diabetic Potential of Cordia dichotoma Pulp and Peel (Functional Fiber) in Type II Diabetic Rats

Sherif Salah Mohamed and Abeer El Sayed Elkhamisy    

Abstract: Background and Objective: A lot of plants have been used traditionally in the treatment diabetic patient for a long time ago. Cordia dichotoma fruits constituents i.e., pulp or seeds comprises of important compounds which have great health benefits. The current study was conducted to investigate the anti-diabetic potential effect of fruits pulp and peel of Cordia dichotoma (C. dichotoma) powder against diabetes mellitus type 2. Materials and Methods: About 24 adult male rats were randomly distributed into to 3 groups each group comprises to 8 rats. The 1st group (I) was fed on the standard normal diet. The 2nd group (II) was given high fat diet (HFD) to induction rats to be obese and after that to be diabetic by long run period and 3rd group (III) was demonstrated HFD+10% of C. dichotoma pulp+peel fiber powder. At the end of the trial, rats were weighted and blood samples were collected for estimating serum biomarkers of diabetes as well as blood glucose, insulin, Leptin and oxidative stress. Results: The results showed that supplemented diet with C. dichotoma powder in 3rd group (III) caused significant increase slightly in body weight gain. Also, The C. dichotoma powder significant decreases in serum levels of blood glucose, AST, ALT, total bilirubin and alkaline phosphatase enzyme in rats. It also had significant increase in serum creatinine. The C. dichotoma powder decreased serum levels of (LDL), triglycerides (TG), total cholesterol (TC) levels, malondialdehyde (MDA) and increased in HDL levels and activity of antioxidant enzymes. Conclusion: Therefore, intake of C. dichotoma pulp+peel fiber powder should be beneficial for the prevention and controlling of diabetic hazards.

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