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International Journal of Pharmacology
Year: 2017  |  Volume: 13  |  Issue: 7  |  Page No.: 864 - 873

Biomaterials-based Hydrogels and their Drug Delivery Potentialities

Angel M. Villalba-Rodriguez, Kuldeep Dhama and Hafiz M.N. Iqbal    

Abstract: In recent years, biomaterials-based hydrogels have gained special attention and moved into mainstream applications in various biomedical sectors. The pristine or improved characteristics of biomaterials-based hydrogels offer unique dimensions in changing the dynamics of 21st-century drug delivery applications. In this context, numerous researchers and research-based organizations have reported uniqueness and novel aspects of various biomaterials for drug delivery purposes and different approaches including in vitro, in vivo and ex-vivo techniques have been exploited, so far. Among various potent biomaterials, chitosan, poly(lactic-co-glycolic acid) (PLGA) and bacterial cellulose are of supreme interests due to their tunable multi-functionalities for an enhanced and efficient delivery. In addition, several characteristics including unique chemical structure, bioactivity, non-toxicity, biocompatibility, biodegradability, recyclability, etc. all positioned them well in various biomedical, pharmaceutical and nutraceutical sectors of the modern world. Herein, we reviewed biomaterials (chitosan, poly(lactic-co-glycolic acid) (PLGA) and bacterial cellulose) based hydrogels and their drug delivery potentialities. The information is also given on considerable future directions that can help in addressing the left behind research gaps and outstanding questions in future studies.

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