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International Journal of Pharmacology
Year: 2017  |  Volume: 13  |  Issue: 3  |  Page No.: 313 - 322

Molecular Characterization of β-lactam Antibiotic Resistant Pseudomonas aeruginosa Isolated from Egyptian Food

Shehab E. Talat, Mahmoud Abd El-Mongy, Mona I. Mabrouk, A.B. Abeer Mohammed and Hanafy A. Hamza    

Abstract: Background and Objective: β-lactam resistant bacteria are emerging highly drug-resistant causing infections accompanied with significant importance. This study was undertaken to detect the β-lactam antibiotic resistant P. aeruginosa obtained from edible foods in El-Giza governorate, Cairo, Egypt and role of the plant oils in reducing β-lactam resistance for P. aeruginosa . Fifty samples from edible food were collected from supermarkets. There are multi drug resistant bacteria presented in the tested edible food. Materials and Methods: Isolation were carried out using classical method by using selective medium then the isolates were identified using modern techniques by PCR and DNA sequencing techniques. Results: Results showed identified isolates were 50 pathogenic bacteria as Staphylococcus spp., 10 isolates (40%), Micrococcus spp., 1 isolate (4%), E. coli 11 isolates (44%), Citrobacter freundii 1 isolate (4%), Enterobacter species 1 isolate (4%), Enterobacter cloacae 1 isolate (4%) and P. aeruginosa 1 isolate (4%). The P. aeruginosa strain was resistance to piperacillin/tazobactam and meropenem, intermediate to gentamicin while sensitive to amikacin, levofloxacin and ciprofloxacin. Moreover, P. aeruginosa strain was sensitive to thyme oil but resistant to fennel, caraway and peppermint oils. Conclusions: Results concluded that treatment β-lactam resistant P. aeruginosa by aminoglycosides or fluoroquinolones antibiotics has significant value. Also, thyme oil considered one of the most important oils in the antimicrobial aspects. Finally treatment of resistant strain of P. aeruginosa by combination of antibiotic and medicenal plants even if resistant to these oils has significant potentiating effect.

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