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International Journal of Pharmacology
Year: 2016  |  Volume: 12  |  Issue: 2  |  Page No.: 74 - 80

Analgesic, Anticonvulsant and Antiparkinsonian Activities of Some Synthesized 2,6-bis(Tetracarboxamide)-pyridine and Macrocyclic Tripeptide Derivatives

Abd El-Galil E Amr, Mohamed A. Al- Omar and Mohamed M. Abdalla    

Abstract: A series of synthesized 2,6-bis(tetracarboxamide)-pyridine and macrocyclic tripeptide derivatives 1-6 were previously prepared and screened as antimicrobial, anti-inflammatory and anticancer agents. The compounds for evaluation of analgesic, anticonvulsant and antiparkinsonian activities were used. Analgesic activities of selected compounds determined by hot plate assay, all tested compounds showed this property. Anticonvulsant activities of selected compounds measured their abilities to antagonize yohimbine-induced clonic seizure, all tested compounds showed this property. The antiparkinsonian activity measured by the ability of compounds to protect animals against the parkinsonian like signs induced by agonists, all tested compounds showed this property. All tested compounds showed analgesic, antipakinsonian and anticonvulsant activities and the order for these activities were 5b, 6a, 3, 5a, 5c, 4, 6c, 2, 6b and 1.

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