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International Journal of Pharmacology
Year: 2016  |  Volume: 12  |  Issue: 5  |  Page No.: 567 - 571

Analgesic Effect of Melanin from (Nigella sativa L.) in the Hotplate Test in Mice (Possible Opioid Receptor Involvement)

Ahmed A. Abdelgalil, Kamal E.H. El-Tahir and A.M. Haseeb    

Abstract: Background: Nigella sativa L. seeds are famous seeds and have been regarded throughout the ages as one of the greatest healing seeds. They possess a vast range of pharmacological actions, among them analgesic effect was indicated. Recently, melanin has been extracted and shown to occur abundantly in the seed coats of Nigella sativa L. Melanin is a ubiquitous pigment of plants and animals. Studies indicated that it is associated with many protective effects but none of these studies addressed analgesic effects of melanin from Nigella sativa (NSM). Objective: This study has been designed to investigate the potential analgesic effects of NSM on hotplate animal models. Methods: Using the hotplate method with different NSM doses 10, 20 and 40 mg kg–1 intra-peritoneal injection (i.p.) in mice animal, reactions times (in seconds) were recorded and then the percent prolongations (% prolongation) and ED50 were calculated. The influence of naloxone 5 mg kg–1 i.p. against NSM 20 mg kg–1 i.p. was also tested. Results: The NSM at 20 and 40 mg kg–1 doses produced statistically significant analgesic effects compared with their control values at 15, 30, 45 and 60 min. A significant effect also produced following a treatment dose 20 mg kg–1 at 90 min. The analgesic effect of NSM was inhibited partially by naloxone (5 mg kg–1) i.p. pretreatment. Conclusion: The obtained data direct the attention to the analgesic activity (central analgesia) of NSM. The effect is primarily assumed to be mediated partly through opioid receptors.

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