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International Journal of Pharmacology
Year: 2016  |  Volume: 12  |  Issue: 4  |  Page No.: 429 - 434

Therapeutic and Biochemical Effects of Garlic (Allium sativum) on Acrylamide Toxicity in Rabbits: Glycolytic Pathway

B. Elmahdi, M.A. Al-Omair, A.A. El-Bessoumy and S.M. El-Bahr    

Abstract: The stimulation of oxidative stress and lipid peroxidation by acrylamide has been extensively documented. However, the effect of acrylamide on glycolytic enzymes has not been completely elucidated. The present study investigated the effect of acrylamide exposure on activities of serum and hepatic glycolytic enzymes namely, pyruvate kinase, glyceraldhyde-3-phoshate dehydrogenase, phosphofructokinase, hexokinase and α-glucosidase in rabbits. In addition, the protective effect of garlic (Allium sativum) against acrylamide toxicity as reflected on glycolytic enzyme activities has been estimated. Rabbits were exposed to acrylamide dissolved at a concentration of 0.03% (w/v, corresponding to 4.2 mM acrylamide) in distilled water with or without diet containing 1.5% of garlic powder for 42 days. Acrylamide administration reduced the activities of all investigated glycolytic enzymes in serum and liver tissues of rabbits. However, administration of garlic powder with acrylamide significantly attenuated the reduction of activities of these enzymes. In conclusion, the present study emphasized the role of garlic as a potential adjuvant therapy to attenuate acrylamide toxicity in rabbits.

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