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International Journal of Pharmacology
Year: 2016  |  Volume: 12  |  Issue: 4  |  Page No.: 422 - 428

Addition of Voglibose to Glimepiride and Metformin have Better Glucose Control in Diabetics: A Prospective, Parallel-group and Open-label Comparative Study

Krishna Murti, Manoj Kumar Sethi, Akalanka Dey, Chandra Sekhar Lal, Krishna Pandey and Pradeep Das    

Abstract: This study compares the change in BMI, fasting and postprandial blood glucose, glycosylated haemoglobin (HbA1c), Glomerular Filtration Rate (GFR), serum creatinine, blood urea and lipid profile levels when two different therapies (group A = metformin+glimepiride) and group B = metformin+glimepiride+voglibose) are given to diabetic patients to compare efficacy of voglibose as an add-on therapy. This study was a 10 months prospective, open-label comparative study. Type II diabetic subjects, aged >18 years were selected and were divided into group A and B. All the parameters were evaluated before the treatment and reassessed after 3 months of treatment. Group A and B was having significant decrease in BMI with p<0.017 and p<0.049, respectively. In both of the groups glucose triad levels decreased significantly as p value found less than 0.05. There was no effect was found over blood urea level. Protective function of kidney observed when voglibose added. Evidence of controlling lipid profile also observed in triple drug therapy as p-value was <0.05. The add-on therapy using voglibose in dual therapy including glimepiride and metformin showed a very significant benefit in controlling the glucose triad levels (HbA1C, fasting plasma glucose and postprandial glucose level) when compared to dual therapy. Voglibose has an effect to decrease Total Cholesterol (TC), triglycerides (TGs) and Low Density Lipoproteins (LDL) level and increase HDL significantly. There was no effect was found on blood urea level.

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