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International Journal of Pharmacology
Year: 2016  |  Volume: 12  |  Issue: 4  |  Page No.: 340 - 350

Impact of Ginkgo biloba Extract on Reproductive Toxicity Induced by Single or Repeated Injection of Cisplatin in Adult Male Rats

Asmaa F. Khafaga and Aida E. Bayad    

Abstract: This study was conducted to evaluate the possible protective effect of Ginkgo biloba (GB) against testicular damage and oxidative stress induced by acute or subchronic intoxication with cisplatin (CIS) in rats. Sixty male albino rats were classified into 6 equal groups (n = 10). Rats were treated orally with 150 mg kg b.wt. day G1 GB extract for 5 successive days before and 25 successive days after induction of toxicity by i.p. injection of CIS. Rats received CIS either acutely as a single injection of CIS (24 mg kg–1 b.wt.) or sub chronically with four equal doses of CIS (6 mg kg–1 b.wt.) once weekly. After 72 h from the last CIS injection, pathological and oxidative testicular toxicity as well as serum testosterone level and sperm indices were evaluated. Rats exposed to subchronic CIS treatment (alone or with prior GB co-treatment) displayed a significant decrease (p<0.05) in reproductive organs weight, caudal sperm count and motility, serum testosterone level and testicular GSH-PX and significant increase (p<0.05) in sperm abnormalities and testicular MDA. This reproductive toxicity was accompanied with necrotic and degenerated lesions in the seminiferous tubules. By contrast, in rats exposed to acute CIS treatment, prior treatment with GB partially ameliorated the subsequent harmful effects of CIS. In conclusion, pretreatment with GB mildly attenuated the reproductive damage induced by single CIS injection, while it failed to improve the damage induced by subchronic treatment.

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