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International Journal of Pharmacology
Year: 2016  |  Volume: 12  |  Issue: 3  |  Page No.: 177 - 187

Antidiabetic and Oxidative Stress Ameliorative Potential of Ethanolic Extract of Pedicularis longiflora Rudolph

Mohd. Iqbal Yatoo, Umesh Dimri, Arumugam Gopalakrishan, Mani Saminathan, Kuldeep Dhama, Karikalan Mathesh, Archana Saxena, Devi Gopinath and Shahid Husain    

Abstract: This study demonstrated the antidiabetic and antioxidant potential of Pedicularis longiflora Rudolph, a Himalayan wild herb, in alloxan induced diabetic rats. Seven groups of wistar rats (n = 6) were divided into healthy control (I) and diabetic control (II) groups, both without any treatment, test groups (III, IV and V) treated with varying concentration of ethanolic extract of Pedicularis longiflora and standard groups treated with N-acetyl cysteine as standard antioxidant (VI) and glibenclamide as standard antidiabetic drug (VII). Diabetic biomarkers and oxidative stress indices were evaluated on day 0, 7 and 14 of treatment. Glucose, glycated haemoglobin (GHb) and fructosamine showed a decrease of 23.08, 33.85 and 43.46%, respectively in group IV than group III (15.06, 46.13 and 23.95%) and group V (15.99, 27.77 and 24.84%) whereas, insulin showed significant (p<0.05) increase in group IV (15.43%) and group V (5.12%), but not than group III (16.82%) on day 14 of treatment. Concentration of reduced glutathione (GSH) and activity of superoxide dismutase (SOD) was increased (p<0.05) whereas, levels of lipid peroxide (LPO) and Nitric Oxide (NO) were decreased (p<0.05) in test groups on day 14 of treatment compared to diabetic control group. Liver homogenate showed lower levels (p<0.05) of LPO and NO, whereas, pancreatic homogenate showed higher levels (p<0.05) of GSH and lower levels (p<0.05) of LPO in test groups. These findings can be attributed to antidiabetic and antioxidant potential of P. longiflora Rudolph, however, group IV (500 mg kg–1 b.wt.) showing better response indicating its safe use as natural medicine.

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