Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
International Journal of Pharmacology
Year: 2015  |  Volume: 11  |  Issue: 4  |  Page No.: 335 - 342

Bicuculline Ameliorated Chronic, but not Acute, Stress-Induced Feeding Suppression

Joo Young Lee, Jin Young Kim, Vitaly Ryu, Bom-Taeck Kim, JaeHyung Koo, Jong-Ho Lee and Jeong Won Jahng    

Abstract: This study was conducted to examine if γ-amino Butyric Acid (GABA)-ergic neurotransmission is implicated in the regulation of stress-induced feeding. Rats received GABAA receptor antagonist bicuculline before each stress session during 10 days of daily restraint stress. The hypothalamic mRNA expressions of corticotropin-releasing hormone and neuropeptide Y were analyzed by in situ hybridization and the plasma corticosterone with radioimmunoassay. Bicuculline ameliorated the decrease in food intake by repeated restraints but not by a single restraint. Corticosterone increase responding to acute stress but not to repeated restraints was attenuated by bicuculline. Stress-induced expression of corticotropin-releasing hormone was blunted by bicuculline pre-treatment. Restraint stress did not affect neuropeptide Y expression, regardless of bicuculline pre-treatment. It is concluded that GABAA receptors may mediate chronic but not acute, stress-induced suppression in food intake, possibly in relation with anorectic action of the hypothalamic corticotropin-releasing hormone and the hypothalamic neuropeptide Y may not be implicated in its regulatory mechanism.

Cited References   |    Fulltext    |   Related Articles   |   Back
   
 
 
 
  Related Articles

 
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility