Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
International Journal of Pharmacology
Year: 2014  |  Volume: 10  |  Issue: 6  |  Page No.: 299 - 306

Efficacy of Plasma Transfusion in Acute Human Organophosphorus Poisoning: A Systematic Review and Meta-analysis

Hadi Mirfazaelian, Shekoufeh Nikfar, Mohammad-Amin Rezvanfar and Mohammad Abdollahi    

Abstract: The present study is a meta-analysis of clinical studies evaluating the efficacy of Fresh Frozen Plasma (FFP) in the treatment of organophosphorus (OP) poisoning. PubMed, Scopus, Google Scholar and clinicaltials.gov were searched for studies investigating the effects of FFP in the treatment of OP poisoning. Mortality, intermediate syndrome (IMS) and hospital stay duration were the key outcomes of interest. Data were searched in the time period of 1966 through April 2014. Three studies that met our inclusion criteria were included in the analysis. Pooling of data showed that the Relative Risk (RR) of mortality in OP poisoning for three included trials comparing FFP to placebo was 0.77 (95% CI = 0.28 to 2.07 (P = 0.6)). The summary of RR for IMS in 2 studies was 0.74 with 95% CI = 0.05 to 10.99 (P = 0.83). The summary of a standard effect for the hospital stay duration in OP poisoning for two trials comparing FFP with placebo was -0.37 with 95% CI = -4.68 to 3.94. According to these data, FFP effect on OP poisoning in mortality, hospital stay duration and IMS incidence was not significant.

Cited References   |    Fulltext    |   Related Articles   |   Back
 
 
   
 
 
 
  Related Articles

 
 
 
 
 
 
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility