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International Journal of Pharmacology
Year: 2014  |  Volume: 10  |  Issue: 5  |  Page No.: 282 - 288

Evaluation of Antioxidant and Antitumor Activities of Lactobacillus acidophilus Bacteria Isolated from Egyptian Infants

Khalid Abd EL Ghany, Ekbal Abd Elhafez, Ragaa A. Hamouda, Hoda Mahrous, Fattah Allah H. Ahmed and Hanafy A. Hamza    

Abstract: Probiotic bacteria are considered beneficial microorganisms and have been widely used. They protect against harmful bacteria that can cause diseases. This study was carried out to evaluate the potential for L. acidophilus intact cells and cell lysates as antioxidant activities and also to evaluate the potential of this bacteria and their exopolysacchariedes (EPS) as antitumor activity in vitro and in vivo against Ehrlich Ascites Carcinoma (EAC) cell line. Lactobacillus acidophilus demonstrated having antioxidant activities for both cell lysates and intact cells with increasing antioxidative properties for cell lysates against 2, 2--diphenyl-1-picrylhydrazyl (DPPH), also resistance to hydrogen peroxide and hydroxyl radical. The EPS produced by L. acidophilus showed a powerful antitumor effect in vivo and in vitro in comparison with L. acidophilus itself while, E. coli increasing solid tumor volume than control.

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