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International Journal of Pharmacology
Year: 2012  |  Volume: 8  |  Issue: 6  |  Page No.: 549 - 554

Effect of Malarial Treatments on Biochemical Parameters and Plasma pH of Mice Infected with Plasmodium berghei

S.O. Olayemi, A.P. Arikawe, A. Akinyede, A.I. Oreagba and O. Awodele    

Abstract: Mice are considered a comparable genetic model to humans and it is well established that mice also exhibit natural differences in susceptibility to malarial infection. The study aimed to determine and compare the effects of artesunate, artesunate+amodiaquine combination, amodiaquine and quinine on biochemical parameters such as liver catalase, plasma glutathione peroxidase, lipid peroxidation, total plasma proteins and plasma pH in the course of a malaria infection. Thirty male albino mice of eight weeks were randomly divided into 6 groups based on the specific antimalarial drug administered and two groups served as control and parasitized untreated groups respectively. The parasite used was a chloroquine-sensitive strain of Plasmodium berghei NK 65, inoculated into mice and observed for twelve days, followed by four days of antimalarial drug administration. Plasma sample was obtained and assay was done for lipid peroxidation, glucose concentration, plasma pH and liver catalase. Plasma pH was significantly lower (p<0.05) in the antimalarial groups compared to the Control and Parasitized untreated groups. Plasma glucose was significantly lower (p<0.05) in the parasitized untreated and antimalarial compared to the control group. Liver catalase was significantly higher (p<0.05) in the Parasitized untreated and antimalarial groups compared to the control group. Lipid peroxidation revealed different results within the antimalarial groups. Artemisinin and its combination with amodiaquine resulted in lowered plasma glucose and greater degree of lipid peroxidation, hence an index of suspicion should be put on possibility of hypoglycaemia with the use of ACTs.

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