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International Journal of Pharmacology

Year: 2012  |  Volume: 8  |  Issue: 4  |  Page No.: 277 - 282

Antihypercholesterolemic Effect of Combination of Guazuma ulmifolia Lamk. Leaves and Curcuma xanthorrhiza Roxb. Rhizomes Extract in Wistar Rats

E.Y. Sukandar, Nurdewi and Elfahmi

Abstract

Guazuma ulmifolia Lamk. (mutamba) and Curcuma xanthorrhiza Roxb. (java turmeric) has been used traditionally as slimming agent and for treating various diseases including hypercholesterolemia. In this study, the effect of aqueous extract of mutamba leaves in combination with ethanol extract of java turmeric has been determined on lipid blood level of Wistar rats compared to each extract alone in hyperlipidemic induced rats. Thirty male rats weighing 180-200 g were divided into six groups receiving mutamba extract, java turmeric extract, simvastatin as a reference of antihyperlipidemic drug, combination of mutamba and java turmeric at two different doses and one control group. The extract was given daily for 14 days at the same time as the administration of propylthiouracil and food high in cholesterol content to induce hyperlipidemia. The serum levels of total cholesterol, triglyceride, HDL and LDL were measured after 3, 7 and 14 days of treatment. The result were analyzed statistically using ANOVA. The results indicated that combination of aqueous extract of mutamba leaves at a dose of 25 mg kg-1 b.wt. and ethanol extract of Java turmeric rhizome at a dose of 12.5 mg kg-1 b.wt. decreased total cholesterol and LDL level significantly compared to control group (p = 0.004) after 7 days of treatments. Aqueous extract of mutamba leaves at a dose of 50 mg kg-1 b.wt. did not show any significant effect while ethanol extract of java turmeric rhizome at a dose of 25 mg kg-1 b.wt. decreased only LDL level significantly.

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