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International Journal of Pharmacology

Year: 2011  |  Volume: 7  |  Issue: 8  |  Page No.: 813 - 820

Exercise Training and Grape Seed Extract Co-administration Improve Endothelial Dysfunction of Mesenteric Vascular Bed in STZ-induced Diabetic Rats

M. Badavi, H.A. Abedi, M. Dianat and A. Sarkaki


Endothelial dysfunction represents a hallmark of diabetic vascular complications. Although, regular exercise training or antioxidants could prevent these complications to some extent, the effects of grape seed extract as an antioxidant alone or combined with exercise on the diabetic induced endothelial dysfunction was not investigated. Therefore, the aim of this study was to determine the combined effect of grape seed extract and exercise training on vascular endothelial function in streptozotocin induced diabetic rats. Forty five male Wistar rats were randomly divided into five groups: Sedentary control, sedentary diabetic, trained diabetic and sedentary or trained diabetic that received 200 mg kg-1grape seed extract. Eight weeks after diabetes induction by streptozotocin (60 mg kg-1) the body weight and blood glucose were measured and mesenteric vascular bed responses to vasoactive agents (acetylcholine, phenylephrine and sodium nitroprusside) were determined. The data have shown that the weight gain, plasma antioxidant capacity and endothelium dependent vasorelaxation to acetylcholine reduced significantly in diabetic animals. However, exercise training combined with grape seed extract improve body weight gain, increase plasma antioxidant capacity, decrease blood glucose and restores vasodilatory response to acetylcholine more significant than exercise training or grape seed extract alone. On the other hand, the vasoconstrictive response to phenylephrine and vasodilatory response to sodium nitroprusside did not change significantly. The data indicated that exercise training and grape seed extract combination had more significant improving effects on endothelial dysfunction than exercise training or grape seed extract alone and may constitute convenient and inexpensive therapeutic approach to diabetic vascular complications.

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