Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
International Journal of Pharmacology
Year: 2011  |  Volume: 7  |  Issue: 7  |  Page No.: 749 - 756

No Superiority of Exenatide over Insulin in Diabetic Patients in Terms of Weight Reduction or Incidence of Adverse Effects: A Meta-analysis

Pooneh Salari, Shekoufeh Nikfar and Mohammad Abdollahi    

Abstract: Recently, exenatide as an incretin mimetic was approved by FDA as an adjunct to diet and exercise in treating type 2 diabetes. Therefore comparing every new medication with insulin can provide more clues about the real benefit of paying extra budget for new drugs. In this meta-analysis we compared the efficacy and tolerability of exenatide to insulin. The literature search provided 1016 articles while only 5 articles were eligible to be included in the meta-analysis with a total of 1404 patients enrolled in the study. The results show that there is no superiority for exenatide over insulin even in its weight reduction advantage. However, the high risk of gastrointestinal side effects including nausea and vomiting is of major concern. Current evidence does not support the advantage of exenatide over insulin but more clinical trials are needed to reach a convincing conclusion.

Cited References   |    Fulltext    |   Related Articles   |   Back
  Related Articles

Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility